mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

Alphaviruses are known to possess a unique viral mRNA capping mechanism involving the viral nonstructural protein nsP1. This enzyme harbors methyltransferase (MTase) and nsP1 guanylylation (GT) activities catalyzing the transfer of the methyl group from S-adenosylmethionine (AdoMet) to the N7 positi...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Li, Changqing, Guillén, Jaime, Rabah, Nadia, Blanjoie, Alexandre, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Decroly, Etienne, Coutard, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524220/
https://ncbi.nlm.nih.gov/pubmed/26041283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00599-15
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