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Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10

The Middle East respiratory syndrome coronavirus (MERS-CoV) nonstructural protein 16 (nsp16) is an S-adenosyl-l-methionine (SAM)-dependent 2′-O-methyltransferase (2′-O-MTase) that is thought to methylate the ribose 2′-OH of the first transcribed nucleotide (N(1)) of viral RNA cap structures. This 2′...

詳細記述

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書誌詳細
出版年:J Virol
主要な著者: Aouadi, Wahiba, Blanjoie, Alexandre, Vasseur, Jean-Jacques, Debart, Françoise, Canard, Bruno, Decroly, Etienne
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309940/
https://ncbi.nlm.nih.gov/pubmed/28031370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02217-16
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