Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

The Flavivirus Zika virus (ZIKV) is the causal agent of neurological disorders like microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a methyltransferase (MTase) domain involved in the formation of the viral mRNA cap. We investigated the structural and functional properties...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Coutard, Bruno, Barral, Karine, Lichière, Julie, Selisko, Barbara, Martin, Baptiste, Aouadi, Wahiba, Lombardia, Miguel Ortiz, Debart, Françoise, Vasseur, Jean-Jacques, Guillemot, Jean Claude, Canard, Bruno, Decroly, Etienne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309936/
https://ncbi.nlm.nih.gov/pubmed/28031359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-16
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