The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation

The large (L) protein of Ebola virus is a key protein for virus replication. Its N-terminal region harbors the RNA-dependent RNA polymerase activity, and its C terminus contains a cap assembling line composed of a capping domain and a methyltransferase domain (MTase) followed by a C-terminal domain...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Valle, Coralie, Martin, Baptiste, Debart, Françoise, Vasseur, Jean-Jacques, Imbert, Isabelle, Canard, Bruno, Coutard, Bruno, Decroly, Etienne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307107/
https://ncbi.nlm.nih.gov/pubmed/32269120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00520-20
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