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A2A Adenosine Receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

Hypoxic and adenosine rich tumor microenvironments represent an important barrier that must be overcome to enable T and NK cells to reject tumors. The A2A adenosine receptor (A2AR) on activated immune cells was identified as a critical and non-redundant mediator of physiological immunosuppression. O...

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Detalhes bibliográficos
Publicado no:Curr Opin Pharmacol
Main Authors: Hatfield, Stephen M., Sitkovsky, Michail
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992656/
https://ncbi.nlm.nih.gov/pubmed/27429212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2016.06.009
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