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A(2A) adenosine receptor gene-deletion or synthetic A(2A) antagonist liberate tumor-reactive CD8(+) T-cells from tumor-induced immunosuppression
Tumor hypoxia-driven accumulation of extracellular adenosine was shown to facilitate tumor evasion by engaging the immunosuppressive, intracellular cAMP-elevating A(2) adenosine receptors (A(2)R) on tumor-reactive effector T cells, but there remains a need in careful evaluation of the limiting facto...
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| 出版年: | J Immunol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052792/ https://ncbi.nlm.nih.gov/pubmed/29802128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700850 |
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