Design and evaluation of xanthine based adenosine receptor antagonists: Potential hypoxia targeted immunotherapies

Molecular modeling techniques were applied to the design, synthesis and optimization of a new series of xanthine based adenosine A(2A) receptor antagonists. The optimized lead compound was converted to a PEG derivative and a functional in vitro bioassay used to confirm efficacy. Additionally, the PE...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Thomas, Rhiannon, Lee, Joslynn, Chevalier, Vincent, Sadler, Sara, Selesniemi, Kaisa, Hatfield, Stephen, Sitkovsky, Michail, Ondrechen, Mary Jo, Jones, Graham B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346301/
https://ncbi.nlm.nih.gov/pubmed/24126093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.09.043
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