PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind D...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Grundy, Gabrielle J., Polo, Luis M., Zeng, Zhihong, Rulten, Stuart L., Hoch, Nicolas C., Paomephan, Pathompong, Xu, Yingqi, Sweet, Steve M., Thorne, Alan W., Oliver, Antony W., Matthews, Steve J., Pearl, Laurence H., Caldecott, Keith W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992063/
https://ncbi.nlm.nih.gov/pubmed/27530147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12404
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