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PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)
PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind D...
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發表在: | Nat Commun |
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Main Authors: | , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
Nature Publishing Group
2016
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4992063/ https://ncbi.nlm.nih.gov/pubmed/27530147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12404 |
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