Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

XRCC1 accelerates repair of DNA single-strand breaks by acting as a scaffold protein for the recruitment of Polβ, LigIIIα, and end-processing factors, such as PNKP and APTX. XRCC1 itself is recruited to DNA damage through interaction of its central BRCT domain with poly(ADP-ribose) chains generated...

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Publicado en:Cell Rep
Autores principales: Polo, Luis M., Xu, Yingqi, Hornyak, Peter, Garces, Fernando, Zeng, Zhihong, Hailstone, Richard, Matthews, Steve J., Caldecott, Keith W., Oliver, Antony W., Pearl, Laurence H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334254/
https://ncbi.nlm.nih.gov/pubmed/30650352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.082
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