Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

Protein ubiquitination involves E1, E2, and E3 trienzyme cascades. E2 and RING E3 enzymes often collaborate to first prime a substrate with a single ubiquitin (UB) and then achieve different forms of polyubiquitination: multiubiquitination of several sites and elongation of linkage-specific UB chain...

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Veröffentlicht in:Cell
Hauptverfasser: Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Weissmann, Florian, Ordureau, Alban, Wu, Kuen-Phon, Zhang, Wei, Yu, Shanshan, Mercredi, Peter Y., Harrison, Joseph S., Davidson, Iain F., Qiao, Renping, Lu, Ying, Dube, Prakash, Brunner, Michael R., Grace, Christy R.R., Miller, Darcie J., Haselbach, David, Jarvis, Marc A., Yamaguchi, Masaya, Yanishevski, David, Petzold, Georg, Sidhu, Sachdev S., Kuhlman, Brian, Kirschner, Marc W., Harper, J. Wade, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991212/
https://ncbi.nlm.nih.gov/pubmed/27259151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.037
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