Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic zebrafish expressing an activated form of the Hippo pathway effector Yap1 (al...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Cox, Andrew G., Hwang, Katie L., Brown, Kristin K., Evason, Kimberley, Beltz, Sebastian, Tsomides, Allison, O'Connor, Keelin, Galli, Giorgio G., Yimlamai, Dean, Chhangawala, Sagar, Yuan, Min, Lien, Evan C., Wucherpfennig, Julia, Nissim, Sahar, Minami, Akihiro, Cohen, David E., Camargo, Fernando D., Asara, John M., Houvras, Yariv, Stainier, Didier Y.R., Goessling, Wolfram
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990146/
https://ncbi.nlm.nih.gov/pubmed/27428308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3389
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