Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic zebrafish expressing an activated form of the Hippo pathway effector Yap1 (al...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Nat Cell Biol
Asıl Yazarlar: Cox, Andrew G., Hwang, Katie L., Brown, Kristin K., Evason, Kimberley, Beltz, Sebastian, Tsomides, Allison, O'Connor, Keelin, Galli, Giorgio G., Yimlamai, Dean, Chhangawala, Sagar, Yuan, Min, Lien, Evan C., Wucherpfennig, Julia, Nissim, Sahar, Minami, Akihiro, Cohen, David E., Camargo, Fernando D., Asara, John M., Houvras, Yariv, Stainier, Didier Y.R., Goessling, Wolfram
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990146/
https://ncbi.nlm.nih.gov/pubmed/27428308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3389
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller