EWS‐FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway

Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS‐FLI1. We report that EWS‐FLI1 suppresses TDO2‐mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS‐FLI1‐dependent regulation of TRP metabolism. TRP consumption incre...

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發表在:FEBS Lett
Main Authors: Mutz, Cornelia N., Schwentner, Raphaela, Kauer, Maximilian O., Katschnig, Anna M., Kromp, Florian, Aryee, Dave N. T., Erhardt, Sophie, Goiny, Michel, Alonso, Javier, Fuchs, Dietmar, Kovar, Heinrich
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2016
主題:
Research Letters
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988508/
https://ncbi.nlm.nih.gov/pubmed/27282934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12243
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