EWS‐FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway

Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS‐FLI1. We report that EWS‐FLI1 suppresses TDO2‐mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS‐FLI1‐dependent regulation of TRP metabolism. TRP consumption incre...

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Enregistré dans:
Détails bibliographiques
Publié dans:FEBS Lett
Auteurs principaux: Mutz, Cornelia N., Schwentner, Raphaela, Kauer, Maximilian O., Katschnig, Anna M., Kromp, Florian, Aryee, Dave N. T., Erhardt, Sophie, Goiny, Michel, Alonso, Javier, Fuchs, Dietmar, Kovar, Heinrich
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Research Letters
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988508/
https://ncbi.nlm.nih.gov/pubmed/27282934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12243
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