CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies

The HIV-1 envelope glycoprotein (Env) is a trimer of gp120/gp41 heterodimers that mediates viral entry. Env binds cellular CD4, an association which stabilizes a conformation favorable to its subsequent association with a coreceptor, typically CCR5 or CXCR4. The CD4- and coreceptor-binding sites ser...

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Udgivet i:J Virol
Main Authors: Gardner, Matthew R., Fellinger, Christoph H., Prasad, Neha R., Zhou, Amber S., Kondur, Hema R., Joshi, Vinita R., Quinlan, Brian D., Farzan, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988152/
https://ncbi.nlm.nih.gov/pubmed/27334589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00803-16
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