Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates

The high-affinity in vivo interaction between soluble HIV-1 envelope glycoprotein (Env) immunogens and primate CD4 results in conformational changes that alter the immunogenicity of the gp120 subunit. Because the conserved binding site on gp120 that directly interacts with CD4 is a major vaccine tar...

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Bibliographische Detailangaben
Hauptverfasser: Douagi, Iyadh, Forsell, Mattias N. E., Sundling, Christopher, O'Dell, Sijy, Feng, Yu, Dosenovic, Pia, Li, Yuxing, Seder, Robert, Loré, Karin, Mascola, John R., Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812383/
https://ncbi.nlm.nih.gov/pubmed/19955308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01896-09
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