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eCD4-Ig Variants That More Potently Neutralize HIV-1

The human immunodeficiency virus type 1 (HIV-1) entry inhibitor eCD4-Ig is a fusion of CD4-Ig and a coreceptor-mimetic peptide. eCD4-Ig is markedly more potent than CD4-Ig, with neutralization efficiencies approaching those of HIV-1 broadly neutralizing antibodies (bNAbs). However, unlike bNAbs, eCD...

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Bibliografiska uppgifter
I publikationen:J Virol
Huvudupphovsmän: Fetzer, Ina, Gardner, Matthew R., Davis-Gardner, Meredith E., Prasad, Neha R., Alfant, Barnett, Weber, Jesse A., Farzan, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974481/
https://ncbi.nlm.nih.gov/pubmed/29593050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02011-17
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