Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson’s pathogenesis. By...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Alexopoulou, Zoi, Lang, Johannes, Perrett, Rebecca M., Elschami, Myriam, Hurry, Madeleine E. D., Kim, Hyoung Tae, Mazaraki, Dimitra, Szabo, Aron, Kessler, Benedikt M., Goldberg, Alfred Lewis, Ansorge, Olaf, Fulga, Tudor A., Tofaris, George K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987833/
https://ncbi.nlm.nih.gov/pubmed/27444016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523597113
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