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Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson’s pathogenesis. By...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4987833/ https://ncbi.nlm.nih.gov/pubmed/27444016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523597113 |
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