Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson’s pathogenesis. By...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Alexopoulou, Zoi, Lang, Johannes, Perrett, Rebecca M., Elschami, Myriam, Hurry, Madeleine E. D., Kim, Hyoung Tae, Mazaraki, Dimitra, Szabo, Aron, Kessler, Benedikt M., Goldberg, Alfred Lewis, Ansorge, Olaf, Fulga, Tudor A., Tofaris, George K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987833/
https://ncbi.nlm.nih.gov/pubmed/27444016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523597113
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