Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma

Cytosolic and organelle-based heat-shock protein (HSP) chaperones ensure proper folding and function of nascent and injured polypeptides to support cell growth. Under conditions of cellular stress, including oncogenic transformation, proteostasis components maintain homeostasis and prevent apoptosis...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Sabnis, Amit J., Guerriero, Christopher J., Olivas, Victor, Sayana, Anin, Shue, Jonathan, Flanagan, Jennifer, Asthana, Saurabh, Paton, Adrienne W., Paton, James C., Gestwicki, Jason E., Walter, Peter, Weissman, Jonathan S., Wipf, Peter, Brodsky, Jeffrey L., Bivona, Trever G.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987817/
https://ncbi.nlm.nih.gov/pubmed/27450084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603883113
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