Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals

The biosynthesis of enveloped viruses depends heavily on the host cell endoplasmic reticulum (ER) glycoprotein quality control (QC) machinery. This dependency exceeds the dependency of host glycoproteins, offering a window for the targeting of ERQC for the development of broad-spectrum antivirals. W...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Caputo, Alessandro T., Alonzi, Dominic S., Marti, Lucia, Reca, Ida-Barbara, Kiappes, J. L., Struwe, Weston B., Cross, Alice, Basu, Souradeep, Lowe, Edward D., Darlot, Benoit, Santino, Angelo, Roversi, Pietro, Zitzmann, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987793/
https://ncbi.nlm.nih.gov/pubmed/27462106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604463113
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