Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

The antiviral activity of UV-4 was previously demonstrated against dengue virus serotype 2 (DENV2) in multiple mouse models. Herein, step-wise minimal effective dose and therapeutic window of efficacy studies of UV-4B (UV-4 hydrochloride salt) were conducted in an antibody-dependent enhancement (ADE...

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Detalhes bibliográficos
Publicado no:Antiviral Res
Main Authors: Warfield, Kelly L., Plummer, Emily M., Sayce, Andrew C., Alonzi, Dominic S., Tang, William, Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Killingbeck, Sarah S., Beatty, P. Robert, Harris, Eva, Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J.L., Kato, Atsushi, Buck, Michael D., King, Kevin, Eddy, William, Khaliq, Mansoora, Sampath, Aruna, Treston, Anthony M., Dwek, Raymond A., Enterlein, Sven G., Miller, Joanna L., Zitzmann, Nicole, Ramstedt, Urban, Shresta, Sujan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064435/
https://ncbi.nlm.nih.gov/pubmed/26946111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.03.001
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