Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes

It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a diverse spectrum of viruses, including dengue vir...

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Foilsithe in:PLoS Negl Trop Dis
Main Authors: Sayce, Andrew C., Alonzi, Dominic S., Killingbeck, Sarah S., Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J. L., Beatty, P. Robert, Kato, Atsushi, Harris, Eva, Dwek, Raymond A., Miller, Joanna L., Zitzmann, Nicole
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790851/
https://ncbi.nlm.nih.gov/pubmed/26974655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004524
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