Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes

It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a diverse spectrum of viruses, including dengue vir...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Sayce, Andrew C., Alonzi, Dominic S., Killingbeck, Sarah S., Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J. L., Beatty, P. Robert, Kato, Atsushi, Harris, Eva, Dwek, Raymond A., Miller, Joanna L., Zitzmann, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790851/
https://ncbi.nlm.nih.gov/pubmed/26974655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004524
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