Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals

The biosynthesis of enveloped viruses depends heavily on the host cell endoplasmic reticulum (ER) glycoprotein quality control (QC) machinery. This dependency exceeds the dependency of host glycoproteins, offering a window for the targeting of ERQC for the development of broad-spectrum antivirals. W...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Caputo, Alessandro T., Alonzi, Dominic S., Marti, Lucia, Reca, Ida-Barbara, Kiappes, J. L., Struwe, Weston B., Cross, Alice, Basu, Souradeep, Lowe, Edward D., Darlot, Benoit, Santino, Angelo, Roversi, Pietro, Zitzmann, Nicole
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987793/
https://ncbi.nlm.nih.gov/pubmed/27462106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604463113
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