Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

The antiviral activity of UV-4 was previously demonstrated against dengue virus serotype 2 (DENV2) in multiple mouse models. Herein, step-wise minimal effective dose and therapeutic window of efficacy studies of UV-4B (UV-4 hydrochloride salt) were conducted in an antibody-dependent enhancement (ADE...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antiviral Res
Egile Nagusiak: Warfield, Kelly L., Plummer, Emily M., Sayce, Andrew C., Alonzi, Dominic S., Tang, William, Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Killingbeck, Sarah S., Beatty, P. Robert, Harris, Eva, Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J.L., Kato, Atsushi, Buck, Michael D., King, Kevin, Eddy, William, Khaliq, Mansoora, Sampath, Aruna, Treston, Anthony M., Dwek, Raymond A., Enterlein, Sven G., Miller, Joanna L., Zitzmann, Nicole, Ramstedt, Urban, Shresta, Sujan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2016
Gaiak:
Short Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064435/
https://ncbi.nlm.nih.gov/pubmed/26946111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.03.001
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