PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis with resultant cytopenias. Increased apoptosis and aberrantly functioning progenitors are thought to contribute to this phenotype. As is the case for other malignancies, overcoming apoptosis is believed to be important in p...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Guirguis, A A, Slape, C I, Failla, L M, Saw, J, Tremblay, C S, Powell, D R, Rossello, F, Wei, A, Strasser, A, Curtis, D J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987724/
https://ncbi.nlm.nih.gov/pubmed/26742432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.159
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