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PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis with resultant cytopenias. Increased apoptosis and aberrantly functioning progenitors are thought to contribute to this phenotype. As is the case for other malignancies, overcoming apoptosis is believed to be important in p...

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Bibliografiska uppgifter
I publikationen:	Cell Death Differ
Huvudupphovsmän:	Guirguis, A A, Slape, C I, Failla, L M, Saw, J, Tremblay, C S, Powell, D R, Rossello, F, Wei, A, Strasser, A, Curtis, D J
Materialtyp:	Artigo
Språk:	Inglês
Publicerad:	Nature Publishing Group 2016
Ämnen:	Original Paper
Länkar:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4987724/ https://ncbi.nlm.nih.gov/pubmed/26742432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.159
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PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

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