BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor–induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3

Constitutively activating internal tandem duplications (ITD) of FLT3 (FMS-like tyrosine kinase 3) are the most common mutations in acute myeloid leukemia (AML) and correlate with poor prognosis. Receptor tyrosine kinase inhibitors targeting FLT3 have developed as attractive treatment options. Becaus...

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Detalhes bibliográficos
Principais autores: Nordigården, Amanda, Kraft, Maria, Eliasson, Pernilla, Labi, Verena, Lam, Eric W.-F., Villunger, Andreas, Jönsson, Jan-Ingvar
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272395/
https://ncbi.nlm.nih.gov/pubmed/19064725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-167023
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