BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor–induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3

Constitutively activating internal tandem duplications (ITD) of FLT3 (FMS-like tyrosine kinase 3) are the most common mutations in acute myeloid leukemia (AML) and correlate with poor prognosis. Receptor tyrosine kinase inhibitors targeting FLT3 have developed as attractive treatment options. Becaus...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nordigården, Amanda, Kraft, Maria, Eliasson, Pernilla, Labi, Verena, Lam, Eric W.-F., Villunger, Andreas, Jönsson, Jan-Ingvar
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272395/
https://ncbi.nlm.nih.gov/pubmed/19064725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-167023
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares