PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis with resultant cytopenias. Increased apoptosis and aberrantly functioning progenitors are thought to contribute to this phenotype. As is the case for other malignancies, overcoming apoptosis is believed to be important in p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Guirguis, A A, Slape, C I, Failla, L M, Saw, J, Tremblay, C S, Powell, D R, Rossello, F, Wei, A, Strasser, A, Curtis, D J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987724/
https://ncbi.nlm.nih.gov/pubmed/26742432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.159
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