Regulation of DJ-1 by glutaredoxin 1 in vivo – implications for Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. Mutations in PARK7 (DJ-1) result in early onset autosomal recessive PD, and oxidative modification of DJ-1 has been reported to regu...

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Udgivet i:Biochemistry
Main Authors: Johnson, William M., Golczak, Marcin, Choe, Kyonghwan, Curran, Pierce L., Miller, Olga Gorelenkova, Yao, Chen, Wang, Wenzhang, Lin, Jiusheng, Milkovic, Nicole M., Ray, Ajit, Ravindranath, Vijayalakshmi, Zhu, Xiongwei, Wilson, Mark A., Wilson-Delfosse, Amy L., Chen, Shu G., Mieyal, John J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987251/
https://ncbi.nlm.nih.gov/pubmed/26894491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01132
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