Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor

Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits inflammation in inflammatory disease models. Therefore...

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Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Gorelenkova Miller, Olga, Cole, Kyle S., Emerson, Corey C., Allimuthu, Dharmaraja, Golczak, Marcin, Stewart, Phoebe L., Weerapana, Eranthie, Adams, Drew J., Mieyal, John J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695812/
https://ncbi.nlm.nih.gov/pubmed/29155853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187991
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