Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI

Osteogenesis imperfecta (OI) Type VI is characterized by a defect in bone mineralization, which results in multiple fractures early in life. Null mutations in the PEDF gene, Serpinf1, are the cause of OI VI. Whether PEDF restoration in a murine model of OI Type VI could improve bone mass and functio...

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Vydáno v:Rare Dis
Hlavní autoři: Belinsky, Glenn S., Ward, Leanne, Chung, Chuhan
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986704/
https://ncbi.nlm.nih.gov/pubmed/27579219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21675511.2016.1212150
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