Pigment epithelium–derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade

Null mutations in for pigment epithelium–derived factor (PEDF), the protein product of the SERPINF1 gene, are the cause of osteogenesis imperfecta (OI) type VI. The PEDF-knockout (KO) mouse captures crucial elements of the human disease, including diminished bone mineralization and propensity to fra...

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Vydáno v:FASEB J
Hlavní autoři: Belinsky, Glenn S., Sreekumar, Bharath, Andrejecsk, Jillian W., Saltzman, W. Mark, Gong, Jingjing, Herzog, Raimund I., Lin, Samantha, Horsley, Valerie, Carpenter, Thomas O., Chung, Chuhan
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2016
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970601/
https://ncbi.nlm.nih.gov/pubmed/27127101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500027R
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