Pigment epithelium–derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade

Null mutations in for pigment epithelium–derived factor (PEDF), the protein product of the SERPINF1 gene, are the cause of osteogenesis imperfecta (OI) type VI. The PEDF-knockout (KO) mouse captures crucial elements of the human disease, including diminished bone mineralization and propensity to fra...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Belinsky, Glenn S., Sreekumar, Bharath, Andrejecsk, Jillian W., Saltzman, W. Mark, Gong, Jingjing, Herzog, Raimund I., Lin, Samantha, Horsley, Valerie, Carpenter, Thomas O., Chung, Chuhan
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970601/
https://ncbi.nlm.nih.gov/pubmed/27127101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500027R
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