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Normal Collagen and Bone Production by Gene-targeted Human Osteogenesis Imperfecta iPSCs
Osteogenesis imperfecta (OI) is caused by dominant mutations in the type I collagen genes. In principle, the skeletal abnormalities of OI could be treated by transplantation of patient-specific, bone-forming cells that no longer express the mutant gene. Here, we develop this approach by isolating me...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256414/ https://ncbi.nlm.nih.gov/pubmed/22031238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.209 |
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