Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour

A central pathological hallmark of Parkinson's disease (PD) is the presence of proteinaceous depositions known as Lewy bodies, which consist largely of the protein α-synuclein (aSyn). Mutations, multiplications and polymorphisms in the gene encoding aSyn are associated with familial forms of PD...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Breda, Carlo, Nugent, Marie L., Estranero, Jasper G., Kyriacou, Charalambos P., Outeiro, Tiago F., Steinert, Joern R., Giorgini, Flaviano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986550/
https://ncbi.nlm.nih.gov/pubmed/25305083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu521
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