Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

BACKGROUND: Ovarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting cytotoxic lymphocytes. Little, however, is known about the effect of adenosine on myeloid cells. Considering that tumor associated m...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Montalbán del Barrio, Itsaso, Penski, Cornelia, Schlahsa, Laura, Stein, Roland G., Diessner, Joachim, Wöckel, Achim, Dietl, Johannes, Lutz, Manfred B., Mittelbronn, Michel, Wischhusen, Jörg, Häusler, Sebastian F. M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986205/
https://ncbi.nlm.nih.gov/pubmed/27532024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0154-9
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