Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

BACKGROUND: Ovarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting cytotoxic lymphocytes. Little, however, is known about the effect of adenosine on myeloid cells. Considering that tumor associated m...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Immunother Cancer
Κύριοι συγγραφείς: Montalbán del Barrio, Itsaso, Penski, Cornelia, Schlahsa, Laura, Stein, Roland G., Diessner, Joachim, Wöckel, Achim, Dietl, Johannes, Lutz, Manfred B., Mittelbronn, Michel, Wischhusen, Jörg, Häusler, Sebastian F. M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2016
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986205/
https://ncbi.nlm.nih.gov/pubmed/27532024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0154-9
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