Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5′-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from oth...

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Autors principals: Deaglio, Silvia, Dwyer, Karen M., Gao, Wenda, Friedman, David, Usheva, Anny, Erat, Anna, Chen, Jiang-Fan, Enjyoji, Keiichii, Linden, Joel, Oukka, Mohamed, Kuchroo, Vijay K., Strom, Terry B., Robson, Simon C.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2007
Matèries:
Brief Definitive Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118603/
https://ncbi.nlm.nih.gov/pubmed/17502665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062512
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