The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas

BACKGROUND: Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME...

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Dades bibliogràfiques
Publicat a:Br J Cancer
Autors principals: Nettersheim, Daniel, Arndt, Isabell, Sharma, Rakesh, Riesenberg, Stefanie, Jostes, Sina, Schneider, Simon, Hölzel, Michael, Kristiansen, Glen, Schorle, Hubert
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Molecular Diagnostics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985348/
https://ncbi.nlm.nih.gov/pubmed/27441500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.187
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