The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas

BACKGROUND: Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Br J Cancer
Κύριοι συγγραφείς: Nettersheim, Daniel, Arndt, Isabell, Sharma, Rakesh, Riesenberg, Stefanie, Jostes, Sina, Schneider, Simon, Hölzel, Michael, Kristiansen, Glen, Schorle, Hubert
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2016
Θέματα:
Molecular Diagnostics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985348/
https://ncbi.nlm.nih.gov/pubmed/27441500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.187
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