The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas

BACKGROUND: Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Nettersheim, Daniel, Arndt, Isabell, Sharma, Rakesh, Riesenberg, Stefanie, Jostes, Sina, Schneider, Simon, Hölzel, Michael, Kristiansen, Glen, Schorle, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985348/
https://ncbi.nlm.nih.gov/pubmed/27441500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.187
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