BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. Seminomas are similar to carcinoma in situ (CIS) cells, the common precursor of type II GCCs, with regard to epigenetics and expression, while embryonal carcinomas (EC) are totipotent and differentiate into teratomas...

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Publicat a:PLoS Genet
Autors principals: Nettersheim, Daniel, Jostes, Sina, Sharma, Rakesh, Schneider, Simon, Hofmann, Andrea, Ferreira, Humberto J., Hoffmann, Per, Kristiansen, Glen, Esteller, Manel B., Schorle, Hubert
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520454/
https://ncbi.nlm.nih.gov/pubmed/26226633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005415
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