HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates

A single-cycle herpes simplex virus (HSV) deleted in glycoprotein D (ΔgD-2) elicited high titer HSV-specific antibodies (Abs) that (i) were rapidly transported into the vaginal mucosa; (ii) elicited antibody-dependent cell-mediated cytotoxicity but little neutralization; (iii) provided complete prot...

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Publicat a:JCI Insight
Autors principals: Petro, Christopher D., Weinrick, Brian, Khajoueinejad, Nazanin, Burn, Clare, Sellers, Rani, Jacobs, William R., Herold, Betsy C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985247/
https://ncbi.nlm.nih.gov/pubmed/27536733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88529
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