Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

BACKGROUND: Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wil...

詳細記述

保存先:
書誌詳細
出版年:Br J Cancer
主要な著者: Ratner, Elena S, Zhu, Yong-Lian, Penketh, Philip G, Berenblum, Julie, Whicker, Margaret E, Huang, Pamela H, Lee, Yashang, Ishiguro, Kimiko, Zhu, Rui, Sartorelli, Alan C, Lin, Z Ping
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
Translational Therapeutics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984868/
https://ncbi.nlm.nih.gov/pubmed/26964031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.54
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