Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

BACKGROUND: Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wil...

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Bibliografski detalji
Izdano u:Br J Cancer
Glavni autori: Ratner, Elena S, Zhu, Yong-Lian, Penketh, Philip G, Berenblum, Julie, Whicker, Margaret E, Huang, Pamela H, Lee, Yashang, Ishiguro, Kimiko, Zhu, Rui, Sartorelli, Alan C, Lin, Z Ping
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Translational Therapeutics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984868/
https://ncbi.nlm.nih.gov/pubmed/26964031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.54
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