Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

BACKGROUND: Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wil...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Ratner, Elena S, Zhu, Yong-Lian, Penketh, Philip G, Berenblum, Julie, Whicker, Margaret E, Huang, Pamela H, Lee, Yashang, Ishiguro, Kimiko, Zhu, Rui, Sartorelli, Alan C, Lin, Z Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984868/
https://ncbi.nlm.nih.gov/pubmed/26964031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.54
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