Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes

Lignende værker

• Expression of O(6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue
  af: Ishiguro, Kimiko, et al.
  Udgivet: (2013)
• The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα
  af: Yalowich, Jack C., et al.
  Udgivet: (2012)
• KS900: a hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells
  af: Baumann, Raymond P., et al.
  Udgivet: (2011)
• Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and KS119W
  af: Penketh, Philip G., et al.
  Udgivet: (2014)
• Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair
  af: Ratner, Elena S, et al.
  Udgivet: (2016)