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Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes

Triapine, currently being evaluated as an antitumor agent in phase II clinical trials, and its terminally dimethylated derivative Dp44mT share the α-pyridyl thiosemicarbazone backbone that functions as ligands for transition metal ions. Yet, Dp44mT is approximately 100-fold more potent than triapine...

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Dettagli Bibliografici
Autori principali: Ishiguro, Kimiko, Lin, Z. Ping, Penketh, Philip G., Shyam, Krishnamurthy, Zhu, Rui, Baumann, Raymond P., Zhu, Yong-Lian, Sartorelli, Alan C., Rutherford, Thomas J., Ratner, Elena S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163625/
https://ncbi.nlm.nih.gov/pubmed/25130544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.08.006
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