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Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens

While the recent success of adeno-associated virus (AAV)-mediated gene therapy in clinical trials is promising, challenges still face the widespread applicability of recombinant AAV(rAAV). A major goal is to enhance the transduction efficiency of vectors in order to achieve therapeutic levels of gen...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nicolson, Sarah C., Li, Chengwen, Hirsch, Matthew L., Setola, Vincent, Samulski, R. Jude
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984620/
https://ncbi.nlm.nih.gov/pubmed/27147738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02953-15
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