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Mechanistic Insights into the Enhancement of Adeno-Associated Virus Transduction by Proteasome Inhibitors

Proteasome inhibitors (e.g., bortezomib, MG132) are known to enhance adeno-associated virus (AAV) transduction; however, whether this results from pleotropic proteasome inhibition or off-target serine and/or cysteine protease inhibition remains unresolved. Here, we examined recombinant AAV (rAAV) ef...

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Bibliografske podrobnosti
Main Authors: Mitchell, Angela M., Samulski, R. Jude
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838122/
https://ncbi.nlm.nih.gov/pubmed/24027330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01826-13
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