Disruption of Microtubules Post-Virus Entry Enhances Adeno-Associated Virus Vector Transduction

Perinuclear retention of viral particles is a poorly understood phenomenon observed during many virus infections. In this study, we investigated whether perinuclear accumulation acts as a barrier to limit recombinant adeno-associated virus (rAAV) transduction. After nocodazole treatment to disrupt m...

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Veröffentlicht in:Hum Gene Ther
Hauptverfasser: Xiao, Ping-Jie, Mitchell, Angela M., Huang, Lu, Li, Chengwen, Samulski, R. Jude
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841008/
https://ncbi.nlm.nih.gov/pubmed/26942476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.008
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